Diet may modify genetic risk for CVD - Cardiology Today

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A high intake of fruits and raw vegetables can potentially modify chromosome 9p21 genetic variants, ultimately lowering the risk for MI and CVD, researchers reported in a recent study.

"One of the most robust genetic associations for CVD is the chromosome 9p21 region," researchers wrote. "However, the interaction of this locus with environmental factors has not been extensively explored."

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The large-scale, multiethnic study included 8,114 participants of the INTER-HEART study, from whom the researchers genotyped four 9p21 single nucleotide polymorphisms (rs10757274, rs2383206, rs10757278, rs1333049) based on results from genome-wide association studies for coronary heart disease, and a follow-up cohort of 19,129 participants from the FINRISK study who had one closely related dietary variable (rs4977574).

Food frequency questionnaires were used to study specific dietary patterns in the INTER-HEART study participants:

  • Oriental (soy sauce, tofu, pickled foods, green leafy vegetables, eggs, and low sugar).
  • Western (eggs, meats, fried and salty foods, sugar, nuts, and desserts).
  • Prudent (raw vegetables, fruits, green leafy vegetables, nuts, desserts, and dairy products).

Overall, all four 9p21 single nucleotide polymorphisms were associated with MI (OR=1.18-1.20).There was a significant interaction between rs2383206 and a prudent diet pattern score. A low prudent diet score was associated with a higher MI risk (OR=1.32), which was diminished in a step-wise fashion in medium (OR=1.17) and high (OR=1.02) prudent diet scores, according to study results.

Similarly, there was a higher CVD risk in low (HR=1.22) or average (HR=1.35) diets of fresh vegetables, fruits and berries vs. a high diet (HR=0.96), when the researchers analyzed participants (including 1,014 incident cases of CVD) of the prospective FINRISK study.

In the INTERHEART study, researchers found a twofold increase in MI risk with a combination of the least prudent diet and two copies of the risk allele (OR=1.98) and a 1.66-fold increase in CVD risk in the FINRISK study (HR=1.66). With the other dietary patterns, researchers found no significant interactions for oriental diet score; western diet score only had an interaction with rs2383206 (P=.028).

Disclosures: The researchers report no relevant financial disclosures.

12 Oct, 2011

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